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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF4E All Species: 39.09
Human Site: S92 Identified Species: 53.75
UniProt: P06730 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P06730 NP_001959.1 217 25097 S92 L M P G C D Y S L F K D G I E
Chimpanzee Pan troglodytes XP_523824 217 24938 S92 L M P G C D Y S L F K D G I E
Rhesus Macaque Macaca mulatta XP_001092045 253 28850 A128 L S S G C D Y A L F K D G I E
Dog Lupus familis XP_544992 217 25075 S92 L M P G C D Y S L F K D G I E
Cat Felis silvestris
Mouse Mus musculus Q3UTA9 244 27967 A120 L S S G C D Y A L F K E G I L
Rat Rattus norvegicus P63074 217 25035 S92 L M P G C D Y S L F K D G I E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514651 236 27161 L101 P L Q N R W A L W F F K N D K
Chicken Gallus gallus XP_420655 217 25026 S92 L M P G C D Y S L F K D G I E
Frog Xenopus laevis P48597 213 24616 S88 L M S G C D Y S L F K D G I E
Zebra Danio Brachydanio rerio Q9DFS6 215 24831 S90 L M S G C D Y S L F K D G I E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48598 259 29205 S136 I K L G S D Y S L F K K N I R
Honey Bee Apis mellifera XP_624290 213 24784 S88 L K Q G C D Y S M F K Q G I R
Nematode Worm Caenorhab. elegans O61955 248 27791 I93 Y Y L F K E G I K P M W E D V
Sea Urchin Strong. purpuratus NP_001091928 225 25645 S100 I T S G C D Y S L F K E G V K
Poplar Tree Populus trichocarpa
Maize Zea mays O81481 218 24452 H101 L I V G A D F H C F K N K I E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O23252 235 26501 Y118 L A H G A D F Y C F K H I I E
Baker's Yeast Sacchar. cerevisiae P07260 213 24236 H94 L P L K S D Y H V F R N D V R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.6 59.2 99.5 N.A. 53.2 98.1 N.A. 71.6 92.1 88.4 82.9 N.A. 43.6 54.8 41.1 53.7
Protein Similarity: 100 98.6 69.1 99.5 N.A. 69.2 98.6 N.A. 74.1 94 94 92.6 N.A. 56.3 68.6 58.8 73.7
P-Site Identity: 100 100 80 100 N.A. 66.6 100 N.A. 6.6 100 93.3 93.3 N.A. 53.3 66.6 0 60
P-Site Similarity: 100 100 86.6 100 N.A. 80 100 N.A. 20 100 93.3 93.3 N.A. 60 73.3 6.6 86.6
Percent
Protein Identity: N.A. 42.2 N.A. 39.5 31.8 N.A.
Protein Similarity: N.A. 56.8 N.A. 54 55.3 N.A.
P-Site Identity: N.A. 46.6 N.A. 46.6 26.6 N.A.
P-Site Similarity: N.A. 66.6 N.A. 53.3 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 6 0 0 12 0 6 12 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 65 0 0 0 12 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 89 0 0 0 0 0 48 6 12 0 % D
% Glu: 0 0 0 0 0 6 0 0 0 0 0 12 6 0 59 % E
% Phe: 0 0 0 6 0 0 12 0 0 95 6 0 0 0 0 % F
% Gly: 0 0 0 83 0 0 6 0 0 0 0 0 65 0 0 % G
% His: 0 0 6 0 0 0 0 12 0 0 0 6 0 0 0 % H
% Ile: 12 6 0 0 0 0 0 6 0 0 0 0 6 77 0 % I
% Lys: 0 12 0 6 6 0 0 0 6 0 83 12 6 0 12 % K
% Leu: 77 6 18 0 0 0 0 6 65 0 0 0 0 0 6 % L
% Met: 0 42 0 0 0 0 0 0 6 0 6 0 0 0 0 % M
% Asn: 0 0 0 6 0 0 0 0 0 0 0 12 12 0 0 % N
% Pro: 6 6 30 0 0 0 0 0 0 6 0 0 0 0 0 % P
% Gln: 0 0 12 0 0 0 0 0 0 0 0 6 0 0 0 % Q
% Arg: 0 0 0 0 6 0 0 0 0 0 6 0 0 0 18 % R
% Ser: 0 12 30 0 12 0 0 59 0 0 0 0 0 0 0 % S
% Thr: 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 6 0 0 0 0 0 6 0 0 0 0 12 6 % V
% Trp: 0 0 0 0 0 6 0 0 6 0 0 6 0 0 0 % W
% Tyr: 6 6 0 0 0 0 77 6 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _